The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

CK2 is a constitutively active Ser/Thr protein kinase which phosphorylates hundreds of
substrates. Since they are primarily related to survival and proliferation pathways, the best …

The PI 3-K signaling pathway has been the subject of intense investigation for over a
decade because it regulates a multitude of cellular processes. Deregulation of this pathway …

The Akt (PKB) protein kinases are critical regulators of human physiology that control an
impressive array of diverse cellular functions, including the modulation of growth, survival …

Structurally, protein kinase CK2 consists of two catalytic subunits (α and α′) and two
regulatory subunits (β), which play a critical role in targeting specific CK2 substrates …

Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …

The scaffold proteins connector enhancer of KSR (CNK) participate in Raf-, Rho-and NF-κB-
dependent signalling and promote cell differentiation and invasion. In this study, we …

Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …

The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide
3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance …

Akt/PKB kinases are central mediators of cell homeostasis. There are three highly
homologous Akt isoforms, Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ. Hyperactivation of Akt …