Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved,
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …

Studies using cultured melanoma cells and patient tumor biopsies have demonstrated
deregulated PI3 kinase-Akt3 pathway activity in~ 70% of melanomas. Furthermore, targeting …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …

Protein kinase CK2 is a protein serine/threonine kinase that exhibits elevated expression in
a number of cancers and displays oncogenic activity in mice. The regulatory CK2β subunit …

Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of widely
divergent cellular processes including proliferation, differentiation, migration, survival and …

The AKT/PKB kinase is a key signaling component of one of the most frequently activated
pathways in cancer and is a major target of cancer drug development. Most studies have …

Protein kinases are central components of signal transduction cascades often dysregulated
in cancer, and they represent some of the most promising drug targets. However, the target …

The serine–threonine kinase AKT regulates proliferation and survival by phosphorylating a
network of protein substrates. In this study, we describe a kinase-independent function of …