Colorectal cancer is the second most frequent cancer in the Western world, often lethal
when invasion and/or metastasis occur. In addition to hepatocyte growth factor (HGF), colon …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Over the past decade cyclooxygenase-2-derived prostaglandins have been implicated in the
development and progression of many types of cancer. Recently our laboratory has shown …

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA.
Colorectal cancer progression and metastasis depends on the orchestration of the aberrant …

Cyclooxygenase (COX)-generated prostaglandin E 2 (PGE 2) plays critical roles in
colorectal carcinogenesis. Recently, we have shown that PGE 2 and transforming growth …

Although colon cancer is one of the most important triggers of cancer related mortality, a few
therapeutic options exist for this disease, including combination chemotherapy, anti-EGFR …

Cyclooxygenase-derived prostaglandin E 2 (PGE 2) is the predominant prostanoid found in
most colorectal cancers (CRC) and is known to promote colon carcinoma growth and …

The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating
evidence has shown that the tumor microenvironment (TME), including macrophages …

Inflammation in the colon contributes significantly to colorectal cancer development. While
aspirin reduces the colorectal cancer risk, its action mechanism, especially in inflammation …

Evidence points towards a pivotal role for cyclooxygenase (COX)-2 in promoting colorectal
tumorigenesis through increasing prostaglandin E 2 (PGE 2) levels. PGE 2 signalling is …