Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers
D Izgelov, E Davidson, D Barasch, A Regev… - European Journal of …, 2020 - Elsevier
Recent advances in the research of medicinal cannabis has placed the non-intoxicating
cannabinoid cannabidiol (CBD) at the front of scientific research. The reasons behind this …
cannabinoid cannabidiol (CBD) at the front of scientific research. The reasons behind this …
[HTML][HTML] Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol
LY Kok, P Bannigan, F Sanaee, JC Evans… - European Journal of …, 2022 - Elsevier
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has
increased in recent years. These drugs often possess physicochemical properties that result …
increased in recent years. These drugs often possess physicochemical properties that result …
A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy …
K Knaub, T Sartorius, T Dharsono, R Wacker… - Molecules, 2019 - mdpi.com
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral
bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known …
bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known …
Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies
LH Silmore, AR Willmer, EV Capparelli… - … : The Journal of …, 2021 - Wiley Online Library
Abstract Cannabidiol (CBD), a non‐psychotropic phytocannabinoid from the Cannabis plant,
is increasingly being pursued as a treatment for differing ailments. The bioavailability and …
is increasingly being pursued as a treatment for differing ailments. The bioavailability and …
Strategies to improve cannabidiol bioavailability and drug delivery
SE O'Sullivan, SS Jensen, AR Kolli, GN Nikolajsen… - Pharmaceuticals, 2024 - mdpi.com
The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development.
The aim of this review was to examine the literature to identify novel oral products and …
The aim of this review was to examine the literature to identify novel oral products and …
Lipid-based formulations to increase cannabidiol bioavailability: In vitro digestion tests, pre-clinical assessment and clinical trial
MAA De Prá, R Vardanega, CG Loss - International Journal of …, 2021 - Elsevier
Herein, medium-chain triglycerides (MCT), glyceryl monolinoleate (GML), and a self-
emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared …
emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared …
[HTML][HTML] A systematic review on the pharmacokinetics of cannabidiol in humans
SA Millar, NL Stone, AS Yates… - Frontiers in …, 2018 - frontiersin.org
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …
Comparative pharmacokinetics of commercially available cannabidiol isolate, broad-spectrum, and full-spectrum products
EC Berthold, SH Kamble, SRR Kanumuri… - European Journal of …, 2023 - Springer
Background and Objectives A wide variety of products containing cannabidiol (CBD) are
available on the commercial market. One of the most common products, CBD oil, is …
available on the commercial market. One of the most common products, CBD oil, is …
A phase 1, randomised, placebo-controlled, dose escalation study to investigate the safety, tolerability and pharmacokinetics of cannabidiol in fed healthy volunteers
Background There is increasing interest in the use of purified cannabidiol (CBD) as a
treatment for a wide range of conditions due to its reported anti-inflammatory, anxiolytic …
treatment for a wide range of conditions due to its reported anti-inflammatory, anxiolytic …
Cannabidiol oil ingested as sublingual drops or within gelatin capsules shows similar pharmacokinetic profiles in healthy males
DA Johnson, MP Funnell, LM Heaney… - Cannabis and …, 2023 - liebertpub.com
Introduction: Cannabidiol (CBD) is a nonintoxicating phytocannabinoid used in clinical
treatments and sold widely in consumer products. CBD products may be designed for …
treatments and sold widely in consumer products. CBD products may be designed for …