Rationale Smoking withdrawal has been widely established to produce a range of
impairments to the quality of several major domains of cognitive function including attention …

Objective: Controversy exists over the effect of tobacco deprivation in nicotine-dependent
individuals and the efficacy of nicotine in reversing performance decrements. This study's …

Introduction: Current FDA-approved smoking cessation pharmacotherapies have limited
efficacy and are associated with high rates of relapse. Therefore, there is a clear need to …

As many as one-half of smokers relapse in the first week following a quit attempt, and
subjective reports of cognitive deficits in early abstinence are associated with increased …

Rationale Smoking abstinence is known to cause decrements in cognition, but the effects
are small and variable. One way to reduce variance may be to aggregate measures or visits …

Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

Rationale and objective Empirical studies indicate that nicotine enhances some aspects of
attention and cognition, suggesting a role in the maintenance of tobacco dependence. The …

Methods Adult daily smokers, n= 160, who were motivated to quit smoking completed
cognitive testing at satiated baseline and after overnight abstinence and then were …

Given the large availability of nicotinic acetylcholine receptors (nAChRs) throughout the
brain, and the wide range of neurotransmitter systems affected (norepinephrine, serotonin …

This paper addresses methodological issues in the assessment of nicotine withdrawal and
craving in clinical trials of smoking cessation therapies. We define withdrawal as a syndrome …