During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-
driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the …

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of
somatic hypermutation and proliferation in dark zones (DZs) and selection in light zones …

Antibody responses are characterized by increasing affinity and diversity over time. Affinity
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of
somatic hypermutation and selection. Selection involves B cells competing for T cell help …

Adaptive immunity involves the development of bespoke antibodies in germinal centers
(GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and …

The germinal center (GC) reaction produces high-affinity antibodies by random mutation and
selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B …

The germinal center (GC) reaction is essential for the generation of the somatically
hypermutated, high-affinity antibodies that mediate adaptive immunity. Entry into the GC is …

B lymphocytes migrate among varied microenvironmental niches during diversification,
selection, and conversion to memory or Ab-secreting plasma cells. Aspects of the nutrient …

Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity
maturation of antibody responses. Here, we examined the mechanism underlying the …

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …