Anticancer drug discovery has yielded unprecedented progress in recent decades, resulting
in the approval of innovative treatment options for patients and the successful …

Most chemotherapeutic agents used today were identified by empirically screening natural
products or synthetic compounds for cytotoxic potency in vitro against murine and/or human …

Cancer is the second leading cause of death worldwide, just behind cardiovascular
diseases. In fact, there was an estimated 18.1 million new cancer cases and 9.6 million …

Efforts of cancer research have yielded significant advance in our understanding on the
complexity of cancer during the past several decades. It is generally accepted that cancer …

Within the context of modern cooperative group trials, modification of standard cytotoxic
chemotherapy has not improved survival in patients with rhabdomyosarcoma (RMS) over …

Recent progress in understanding the molecular basis of cancer has redefined the
landscape for cancer drug discovery and development. Among the most exciting and …

In an era of increased focus on precision medicine, tumour-agnostic therapies have
emerged as a revolutionary new approach to cancer treatment. Tumour-agnostic therapies …

There is an apparent need to improve the speed and efficiency of oncological drug
development. Furthermore, strategies traditionally applied to the development of standard …

Every new anti-cancer drug or drug combination is evaluated for safety and efficacy before
being approved. Clinical development of cytotoxic anticancer drugs classically follows three …

Complex enzyme interactions play a role in the spread of cancer, a process fueled by
unregulated cell proliferation. DNA topoisomerases, which are important for fixing DNA …