Fas ligand (FasL/CD95L) is best known for its role in delivering apoptotic signals through its
receptor, Fas (APO-1/CD95). In this study, we present evidence that FasL has a second role …

TNFα binds to two distinct, type I membrane receptors One of the hallmarks of the immune
system is the con- on the cell surface, TNFR-1 (p55/p60) and TNFR-2 (p75/stant expansion …

GITR (glucocorticoid‐induced TNFR family related gene) is a member of the TNFR
superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes …

In addition to signals from the T‐cell receptor complex, it has been recognized for many
years that a 'second'signal, most notably from CD28, is also important in T‐cell activation. In …

T lymphocytes play a key role in immunity by distinguishing self from nonself peptide
antigens and regulating both the cellular and humoral arms of the immune system. Acquired …

Receptors belonging to the TNF-receptor (TNF-R) superfamily include important
costimulatory molecules, many of which specifically affect T cell activation. TNF receptor …

Glucocorticoid-induced TNFR (GITR) is a member of the TNFR family that can inhibit the
suppressive function of regulatory T cells and promote the survival and activation of T cells …

Positive and negative costimulation by members of the CD28 family is critical for the
development of productive immune responses against foreign pathogens and their proper …

As the recognition that costimulatory signals are critical for optimal T‐cell activation,
proliferation, and differentiation, there has been an explosion in the study of costimulatory …

The glucocorticoid-induced TNF receptor (GITR), which is a member of the TNF receptor
family, is expressed preferentially at high levels on CD25+ CD4+ regulatory T cells and …