VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum

MF Duffy, AG Maier, TJ Byrne, AJ Marty… - Molecular and …, 2006 - Elsevier
Malaria during pregnancy causes serious disease that is associated with sequestration in
the placenta of Plasmodium falciparum infected erythrocytes that adhere to several host …

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A

NK Viebig, B Gamain, C Scheidig, C Lépolard… - EMBO …, 2005 - embopress.org
In high‐transmission regions, protective clinical immunity to Plasmodium falciparum
develops during the early years of life, limiting serious complications of malaria in young …

Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women

AF Sander, A Salanti, T Lavstsen… - Journal of Infectious …, 2011 - academic.oup.com
Placental malaria infections are caused by Plasmodium falciparum–infected red blood cells
sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a …

Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA

M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …

Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-Adherent Plasmodium falciparum-Infected Erythrocytes Are Associated with Transcription of var2csa

SR Elliott, MF Duffy, TJ Byrne, JG Beeson… - Infection and …, 2005 - Am Soc Microbiol
Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …

Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype

NK Viebig, E Levin, S Dechavanne, SJ Rogerson… - PloS one, 2007 - journals.plos.org
Infection with Plasmodium falciparum during pregnancy is one of the major causes of
malaria related morbidity and mortality in newborn and mothers. The complications of …

The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1

JC Reeder, AF Cowman, KM Davern… - Proceedings of the …, 1999 - National Acad Sciences
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium
falciparum in the placenta, but the parasite ligand involved in adhesion has not previously …

Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies

JP Semblat, A Raza, SA Kyes, JA Rowe - Molecular and biochemical …, 2006 - Elsevier
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …

High Level of var2csa Transcription by Plasmodium falciparum Isolated from the Placenta

NG Tuikue Ndam, A Salanti, G Bertin… - The Journal of …, 2005 - academic.oup.com
Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique
variant surface antigens that are involved in the placental sequestration that precipitates …

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …