VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum
MF Duffy, AG Maier, TJ Byrne, AJ Marty… - Molecular and …, 2006 - Elsevier
Malaria during pregnancy causes serious disease that is associated with sequestration in
the placenta of Plasmodium falciparum infected erythrocytes that adhere to several host …
the placenta of Plasmodium falciparum infected erythrocytes that adhere to several host …
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A
NK Viebig, B Gamain, C Scheidig, C Lépolard… - EMBO …, 2005 - embopress.org
In high‐transmission regions, protective clinical immunity to Plasmodium falciparum
develops during the early years of life, limiting serious complications of malaria in young …
develops during the early years of life, limiting serious complications of malaria in young …
Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women
Placental malaria infections are caused by Plasmodium falciparum–infected red blood cells
sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a …
sequestering in the placenta by binding to chondroitin sulfate A, mediated by VAR2CSA, a …
Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-Adherent Plasmodium falciparum-Infected Erythrocytes Are Associated with Transcription of var2csa
SR Elliott, MF Duffy, TJ Byrne, JG Beeson… - Infection and …, 2005 - Am Soc Microbiol
Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …
Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
NK Viebig, E Levin, S Dechavanne, SJ Rogerson… - PloS one, 2007 - journals.plos.org
Infection with Plasmodium falciparum during pregnancy is one of the major causes of
malaria related morbidity and mortality in newborn and mothers. The complications of …
malaria related morbidity and mortality in newborn and mothers. The complications of …
The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
JC Reeder, AF Cowman, KM Davern… - Proceedings of the …, 1999 - National Acad Sciences
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium
falciparum in the placenta, but the parasite ligand involved in adhesion has not previously …
falciparum in the placenta, but the parasite ligand involved in adhesion has not previously …
Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies
JP Semblat, A Raza, SA Kyes, JA Rowe - Molecular and biochemical …, 2006 - Elsevier
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …
High Level of var2csa Transcription by Plasmodium falciparum Isolated from the Placenta
NG Tuikue Ndam, A Salanti, G Bertin… - The Journal of …, 2005 - academic.oup.com
Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique
variant surface antigens that are involved in the placental sequestration that precipitates …
variant surface antigens that are involved in the placental sequestration that precipitates …
Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes
M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …