The dysregulation of inflammatory responses and of immune self-tolerance is considered to
be a key element in the autoreactive immune response in multiple sclerosis (MS) …

Introduction Multiple sclerosis (MS) is a complex genetic disease characterized by chronic
inflammation of the central nervous system (CNS). The pathology of MS is largely attributed …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS). In the recent years, accumulating evidence has supported an …

The role of CD8+ T cells in the process of autoimmune pathology has been both
understudied and controversial. Multiple sclerosis (MS) is an inflammatory, demyelinating …

A sustained neuroinflammatory response is the hallmark of many neurodegenerative
diseases, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis …

Regulatory T (Treg) cells are a special subpopulation of immunosuppressive T cells that are
essential for sustaining immune homeostasis. They maintain self‐tolerance, inhibit …

Background Accumulating evidence indicates that regulatory T cells (Tregs) play an
important role in the maintenance of immune tolerance. And dysfunction or deficiency of …

Multiple sclerosis (MS) is often characterized by several relapses and remissions during
long-term disease, but neither the responsible cells nor the mechanisms are known to date …

The pathological features of multiple sclerosis (MS), a chronic inflammatory disorder of the
central nervous system, support an autoimmune etiology. Strong evidence has been …

Multiple sclerosis (MS) is a debilitating, chronic inflammatory disorder of the central nervous
system (CNS) that is characterized by heterogeneous patterns of neurological symptoms …