New therapeutic nonpharmacological methodology in Parkinson's disease (PD) involves
cell and synaptic renewal or replacement to restore function of neuronal systems, including …

Growing evidence has demonstrated that neurogenesis in the subventricular zone (SVZ) is
significantly decreased in Parkinson's disease (PD). Modulation of endogenous …

The main motor symptoms of Parkinson's disease are due to the loss of dopaminergic (DA)
neurons in the ventral midbrain (VM). For the future treatment of Parkinson's disease with …

The derivation of dopaminergic neurons from induced pluripotent stem cells brings new
hope for a patient-specific, stem cell-based replacement therapy to treat Parkinson's disease …

Transplantation of exogenous dopaminergic neuron (DA neurons) is a promising approach
for treating Parkinson's disease (PD). However, a major stumbling block has been the lack of …

Transplantation of neural progenitor cells (NPCs) is a potential therapy for treating
neurodegenerative disorders, but this approach has faced many challenges and limited …

Stem cells have been widely assumed to be capable of replacing lost or damaged cells in a
number of diseases, including Parkinson's disease (PD), in which neurons of the substantia …

The clinical studies with intrastriatal transplants of fetal mesencephalic tissue in Parkinson's
disease (PD) patients have provided proof-of-principle for the cell replacement strategy in …

The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to
their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's …

The transplantation of pluripotent stem-cell-derived neurons constitutes a promising avenue
for the treatment of several brain diseases. However, their potential for the repair of the …