Mitochondria are maternally inherited, semi-autonomous organelles with their own genomes
(mtDNA), largely responsible for the generation of energy in the form of cellular ATP …

Mitochondria are cellular organelles regulating metabolism and cell death pathways. This
study examined changes in mitochondrial membrane potential (ΔΨm) throughout the stages …

The strictly maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) in
mammals is a developmental paradox promoted by an unknown mechanism responsible for …

Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of
reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly …

With rare exceptions, mammalian mitochondria are inherited through the female. This
probably serves to minimize lethal cytoplasmic gene competition and to prevent the …

Background In human oocytes, as in other mammalian ova, there is a significant variation in
the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial
replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST) …