An increasing number of women fail to achieve pregnancy due to either failed fertilization or
embryo arrest during preimplantation development. This often results from decreased oocyte …

Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential
pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood …

Spermatogenesis is a highly complex, hormonally regulated cytodifferentiation process
finally leading to the production of spermatozoa. In addition to other events germ cell …

The capacity of stem cells to self-renew or differentiate has been attributed to distinct
metabolic states. A genetic screen targeting regulators of mitochondrial dynamics revealed …

Optimal maturation of the oocyte depends on its environment and determines embryo
competence, because the embryonic genome is not active until the cleavage stage and new …

Mitochondria are dynamic organelles that continually adapt their structure through fusion
and fission in response to changes in their bioenergetic environment. Targeted deletion of …

Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

Mitochondria are dynamic organelles that change their morphology by active fusion and
fission in response to cellular signaling and differentiation [1, 2]. The in vivo role of …

STUDY QUESTION Does the oxygen concentration in the culture medium [either physiologic
(5%) or atmospheric (20%)] affect mitochondrial ultrastructure and function in …

Objective To reveal the relationship between mitochondrial function in cumulus cells (CCs)
and the aging-related decline in ovarian function and reproductive capacity. Design …