Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …

Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic
effects on neighbouring pre-malignant cells through the senescence-associated secretory …

Oncogene-induced senescence (OIS) is characterized by increased expression of the cell
cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context …

INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

Cellular senescence is historically associated with cancer suppression and aging. Recently,
the reach of the senescence genetic program has been extended to include the ability of …

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically,
senescence also induces an inflammatory secretome that promotes carcinogenesis and age …

Cellular senescence is a stress response program characterized by a robust cell cycle arrest
and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …