The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …

Cellular senescence suppresses cancer by arresting the proliferation of cells at risk for
malignant transformation. Recently, senescent cells were shown to secrete numerous …

Drug induced resistance is a widespread problem in the clinical management of cancer.
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

The senescence-associated secretory phenotype (SASP) can be provoked by side effects of
therapeutic agents, fueling advanced complications including cancer resistance. However …

Senescence is a cellular phenotype present in health and disease, characterized by a stable
cell-cycle arrest and an inflammatory response called senescence-associated secretory …

Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective
response to oncogenic events, serving to eliminate early neoplastic cells from the …

Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells
upon oncogene activation. Cells undergoing OIS express a wide variety of secreted factors …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Senescence is a double-edged sword that can function in opposite directions. It is a
potential mechanism for a cell to avoid malignant transformation. However, senescence can …