Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective
response to oncogenic events, serving to eliminate early neoplastic cells from the …

Senescence is a double-edged sword that can function in opposite directions. It is a
potential mechanism for a cell to avoid malignant transformation. However, senescence can …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

Senescent cells, albeit not proliferating, are metabolically and transcriptionally active,
thereby capable of affecting their microenvironment, notably via the production of …

The well-recognized cell phenotypic heterogeneity in tumors is a great challenge for cancer
treatment. Dynamic interconversion and movement within a spectrum of different cell …

Aging is defined as a progressive decrease in physiological function accompanied by a
steady increase in mortality. The antagonistic pleiotropy theory proposes that aging is …

Background There is compelling evidence associating senescent cells with the malignant
progression of tumours. Of all senescence-related mechanisms, the so-called senescence …

Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …