Persistence of BCR-ABL rearrangements was demonstrated by D-FISH technique in chronic
myeloid leukemia (CML) patients in complete cytogenetic response (CCR) after allogeneic …

In recent years, the prognosis of chronic myeloid leukemia (CML) has been greatly improved
either with interferon-(IFN-) therapy or allogeneic bone marrow transplantation (BMT). In …

In chronic myelogenous leukemia (CML), amplification of a segment of bcr-abl messenger
RNA (mRNA) by polymerase chain reaction (PCR) can be used to detect minimal residual …

Cytogenetic, interphase fluorescent in situ hybridization (FISH) and RT-PCR methods were
used to study minimal residual disease in peripheral blood stem cells collected for …

Chronic myeloid leukemia (CML) is the prototype cytogenetic malignancy. Even before the
development of basic G-banding techniques, CML was found to be associated with a …

In most patients with chronic myelogenous leukemia (CML) primitive hematopoietic
progenitors carry the acquired reciprocal bcr/abl gene rearrangement t (9; 22)(q34. 1; q11 …

Polymerase chain reaction (PCR) is a powerful and rapid method for specifically detecting
BCR–ABL rearrangement by amplification of the complementary DNA (cDNA) produced by …

The translocation t (9; 22) in chronic myeloid leukemia (CML) generates a bcr-abl fusion
gene that codes for an aberrant chimeric mRNA. Cell lines established from CML patients in …

The use of the real-time reverse-transcription polymerase-chain reaction (RT-PCR) method
to quantify BCR-ABL transcripts before and after allogeneic transplant was prospectively …

Abstract The Philadelphia chromosome (Ph) derives from the balanced translocation
between chromosomes 9 and 22. This chromosomal translocation results in the fusion …