The development of cancer is generally believed to occur by a multistep process in which
critical genetic defects accumulate in a clone of cells, confer a growth advantage, and result …

The actual significance of the type of BCR-ABL rearrangement in chronic myeloid leukemia
(CML) prognosis remains controversial. Also, the molecular events that lead to CML …

Abstract Background The BCR/ABL gene rearrangement is generated by a reciprocal
translocation t (9; 22)(q34; q11) in chronic myeloid leukemia (CML) patients. In most cases, it …

For patients with chronic myeloid leukaemia, methods for monitoring response to treatment
have changed considerably in recent years. In the 1980s, the principal approach was …

The BCR/ABL gene rearrangement is cytogenetically visualized in most chronic myeloid
leukemia (CML) cases. About 5–10% of CML patients lack its cytogenetic evidence …

BACKGROUND AND OBJECTIVES: The most common translocation in chronic myeloid
leukemia (CML) t (9; 22)(q34; q22) produces the BCR/ABL fusion gene. We set up and …

Molecular monitoring of BCR–ABL1 transcript levels using quantitative polymerase chain
reaction is an essential part of the modern management of chronic myeloid leukemia …

Background To analyze the frequency of atypical fluorescence in situ hybridization signal
patterns and estimate the complete cytogenetic response (CCyR) and major molecular …

We have used a new single‐step real‐time reverse transcription polymerase chain reaction
(RT‐PCR) method to quantify BCR‐ABL transcripts, thereby estimating the relapse stage in …

Median duration of the chronic phase of chronic myelogenous leukemia (CML) is 3 years;
less than 20% of patients have a chronic phase greater than 7 years. It is unknown whether …