The genetics, neurogenetics and pharmacogenetics of addiction

CH Demers, R Bogdan, A Agrawal - Current behavioral neuroscience …, 2014 - Springer
Addictions are prevalent psychiatric disorders that confer remarkable personal and social
burden. Despite substantial evidence for their moderate, yet robust, heritability (approx …

The genetics of addiction—a translational perspective

A Agrawal, KJH Verweij, NA Gillespie, AC Heath… - Translational …, 2012 - nature.com
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Human genetics of addiction: new insights and future directions

DB Hancock, CA Markunas, LJ Bierut… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Addiction and its brain science

R Spanagel, M Heilig - Addiction, 2005 - Wiley Online Library
Aims To illustrate how modern neurobiological approaches will help to identify the
neurocircuits and genes involved in addictive behavior. Background The current disorder …

Breaking barriers in the genomics and pharmacogenetics of drug addiction

MK Ho, D Goldman, A Heinz, J Kaprio… - Clinical …, 2010 - Wiley Online Library
Drug addiction remains a substantial health issue with limited treatment options currently
available. Despite considerable advances in the understanding of human genetic …

New insights into the genetics of addiction

MD Li, M Burmeister - Nature Reviews Genetics, 2009 - nature.com
Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

Neuroepigenetics and addiction

DM Walker, EJ Nestler - Handbook of clinical neurology, 2018 - Elsevier
Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Neural markers of genetic vulnerability to drug addiction

DJ Müller, O Likhodi, A Heinz - Behavioral neuroscience of drug addiction, 2010 - Springer
This chapter will summarize genetics findings derived from various strategies and highlight
important neural markers (or correlates) in some specific and extensively studied genes …

The genetics of addictions: uncovering the genes

D Goldman, G Oroszi, F Ducci - Focus, 2006 - Am Psychiatric Assoc
The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …

The role of epigenetics in addiction: clinical overview and recent updates

A Beayno, S El Hayek, P Noufi, Y Tarabay… - … Disorders: Methods and …, 2019 - Springer
Addiction is an international public health problem. It is a polygenic disorder best
understood by accounting for the interplay between genetic and environmental factors. A …