Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
M Bolis, D Bossi, A Vallerga, V Ceserani… - Nature …, 2021 - nature.com
Comprehensive genomic studies have delineated key driver mutations linked to disease
progression for most cancers. However, corresponding transcriptional changes remain …
progression for most cancers. However, corresponding transcriptional changes remain …
Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer
How prostate cancer cells and their precursors mediate changes in the tumor
microenvironment (TME) to drive prostate cancer progression is unclear, in part due to the …
microenvironment (TME) to drive prostate cancer progression is unclear, in part due to the …
Integrative biology of prostate cancer progression
SA Tomlins, MA Rubin… - Annu. Rev. Pathol. Mech …, 2006 - annualreviews.org
Prostate cancer displays considerable clinical, morphological, and biological heterogeneity.
Classical genetic techniques have provided only limited information about the pathogenesis …
Classical genetic techniques have provided only limited information about the pathogenesis …
Single-Cell RNA-seq reveals a subpopulation of prostate cancer cells with enhanced cell-Cycle–Related transcription and attenuated androgen response
Increasing evidence suggests the presence of minor cell subpopulations in prostate cancer
that are androgen independent and poised for selection as dominant clones after androgen …
that are androgen independent and poised for selection as dominant clones after androgen …
[HTML][HTML] The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing
Prostate cancer is a leading cause of global cancer-related death but attempts to improve
diagnoses and develop novel therapies have been confounded by significant patient …
diagnoses and develop novel therapies have been confounded by significant patient …
Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer
Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
A radiogenomic approach for decoding molecular mechanisms underlying tumor progression in prostate cancer
S Fischer, M Tahoun, B Klaan, KM Thierfelder… - Cancers, 2019 - mdpi.com
Prostate cancer (PCa) is a genetically heterogeneous cancer entity that causes challenges
in pre-treatment clinical evaluation, such as the correct identification of the tumor stage …
in pre-treatment clinical evaluation, such as the correct identification of the tumor stage …
Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories
Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease
Prostate cancer is initially responsive to androgen ablation therapy and progresses to
androgen-unresponsive states that are refractory to treatment. The mechanism of this …
androgen-unresponsive states that are refractory to treatment. The mechanism of this …
Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease
E LaTulippe, J Satagopan, A Smith, H Scher… - Cancer research, 2002 - AACR
The identification of genes that contribute to the biological basis for clinical heterogeneity
and progression of prostate cancer is critical to accurate classification and appropriate …
and progression of prostate cancer is critical to accurate classification and appropriate …
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