Adjuvant activity of CpG oligodeoxynucleotides
DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
CpG DNA as a vaccine adjuvant
C Bode, G Zhao, F Steinhagen, T Kinjo… - Expert review of …, 2011 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
CpG DNA as a vaccine adjuvant
DM Klinman - Expert review of vaccines, 2003 - Taylor & Francis
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
DM Klinman, S Klaschik, T Sato, D Tross - Advanced drug delivery reviews, 2009 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants
DM Klinman, S Klaschik, K Tomaru, H Shirota, D Tross… - Vaccine, 2010 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and …
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and …
Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides
CA Leifer, D Verthelyi, DM Klinman - Journal of Immunotherapy, 2003 - journals.lww.com
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger an
immune response characterized by proliferation, B-cell activation, and cytokine production …
immune response characterized by proliferation, B-cell activation, and cytokine production …
Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer
J Scheiermann, DM Klinman - Vaccine, 2014 - Elsevier
Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
Treatment of infectious diseases with immunostimulatory oligodeoxynucleotides containing CpG motifs
U Dittmer, ARM Olbrich - Current Opinion in Microbiology, 2003 - Elsevier
Bacterial DNA with CpG motifs can efficiently stimulate the vertebrate immune system. Thus,
synthetic oligodeoxynucleotides that contain such CpG motifs (CpG-ODN) are currently used …
synthetic oligodeoxynucleotides that contain such CpG motifs (CpG-ODN) are currently used …