The vertebrate immune system has evolved a mechanism to detect CpG motifs within
microbial DNA (CpG DNA). Synthetic oligonucleotides containing CpG motifs (CpG ODNs) …

Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to
activate the innate immune system. The resultant response limits the early spread of …

CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs
that were originally discovered in bacterial DNA, are demonstrated not only as potent …

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs trigger an
immune response characterized by the activation of B cells, NK cells and monocytes …

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and …

We have previously reported that synthetic oligodeoxynucleotides containing
immunostimulatory CpG motifs (CpG ODN) are potent adjuvants to protein administered by …

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants, improving the immune response elicited by co-administered vaccines. Combining …

Several types of immune cells possess pattern recognition receptors (PRR) that can
distinguish prokaryotic DNA from vertebrate DNA by detecting unmethylated CpG …

Bacterial DNA and immunostimulatory CpG oligodeoxynucleotides (ODNs) activate the
innate immune system to produce proinflammatory cytokines. Shown to be potent Th1-like …

Synthetic oligodeoxynucleotides containing CG motifs (CpG ODNs) have potent
immunostimulatory properties, and have potential as immunotherapeutic agents in cancer …