Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
T Sparwasser, ES Koch, RM Vabulas… - European journal of …, 1998 - Wiley Online Library
Bacterial DNA and immunostimulatory (is) synthetic CpG‐oligodeoxynucleotides (ODN) act
as adjuvants for Th1 responses and cytotoxic T cell responses to proteinaceous antigens …
as adjuvants for Th1 responses and cytotoxic T cell responses to proteinaceous antigens …
Immunopharmacology of CpG DNA
A Dalpke, S Zimmermann, K Heeg - 2002 - degruyter.com
Recognition of danger of infection by innate immune cells is a prerequisite to combat
infections and to activate T and B cells. Pathogenassociated molecular patterns (PAMP) play …
infections and to activate T and B cells. Pathogenassociated molecular patterns (PAMP) play …
[PDF][PDF] Recent advances in the development of immunostimulatory oligonucleotides
E Uhlmann, J Vollmer - Current Opinion in Drug Discovery and …, 2003 - researchgate.net
Some immune cells recognize distinct molecular structures present in pathogens through
specific pattern recognition receptors that are able to distinguish prokaryotic DNA from …
specific pattern recognition receptors that are able to distinguish prokaryotic DNA from …
[HTML][HTML] CpG DNA: recognition by and activation of monocytes
Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …
The role of CpG dinucleotides in DNA vaccines
AM Krieg, AK Yi, J Schorr, HL Davis - Trends in microbiology, 1998 - cell.com
DNA vaccines can induce potent humoral and cellular immune responses without any
additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within …
additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within …
Enhanced immunostimulatory activity of oligodeoxynucleotides by Y‐shape formation
M Nishikawa, M Matono, S Rattanakiat… - …, 2008 - Wiley Online Library
DNA containing unmethylated CpG dinucleotides (CpG DNA) is a potent activator of innate
and acquired immune responses. Although the sequence‐specific immunostimulatory …
and acquired immune responses. Although the sequence‐specific immunostimulatory …
Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences
D Yu, ER Kandimalla, Y Cong, J Tang… - Journal of medicinal …, 2002 - ACS Publications
Bacterial and synthetic DNA containing unmethylated CpG dinucleotides activate the innate
immune system and promote Th1-like immune responses. Recently, a receptor, TLR9, has …
immune system and promote Th1-like immune responses. Recently, a receptor, TLR9, has …
Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection
DM Klinman, J Conover, C Coban - Infection and immunity, 1999 - Am Soc Microbiol
Synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate an
innate immune response characterized by the production of polyreactive immunoglobulin M …
innate immune response characterized by the production of polyreactive immunoglobulin M …
Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis
T Sparwasser, L Hultner, ES Koch, A Luz… - The Journal of …, 1999 - journals.aai.org
Bacterial DNA and the synthetic CpG-oligodeoxynucleotides (ODNs) derived thereof have
attracted attention because they activate cells of the adaptive immune system (lymphocytes) …
attracted attention because they activate cells of the adaptive immune system (lymphocytes) …
C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level
M Jurk, B Schulte, A Kritzler, B Noll, E Uhlmann… - Immunobiology, 2004 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine–
deoxyguanosine (CpG) motifs are very potent inducers of the innate immune system …
deoxyguanosine (CpG) motifs are very potent inducers of the innate immune system …