The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino) 2, 1, 3-
benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and …

Abstract Tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiadiazole] is able to
increase the pain threshold in the tail-flick test in mice. The effect of tizanidine was …

The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or …

Experiments were performed in rats to determine if the [alpha] 2-adrenergic agonist
tizanidine has an antinociceptive effect when injected intrathecally, and whether the …

BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby
affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α 2 …

The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-
chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzo-thiadiazole] were investigated by …

Experiments in cats anesthetized with α-chloralose showed that tizanidine (TZD: 5-chloro-4-
(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiodiazole) partly resembled carbamazepine (CBZ) …

The antinociceptive responses to the γ-aminobutyric acid receptor agonists THIP (4, 5, 6, 7-
tetrahydroisoxazolo [5, 4-c] pyridine-3-ol) and baclofen were examined in spinally …

The effects of the centrally acting muscle relaxant tizanidine (DS 103-282) have been
examined on the responses of laminae IV and V dorsal horn neurones to peripheral noxious …