Hypercapnic exposure in congenital central hypoventilation syndrome reveals CNS respiratory control mechanisms

RM Harper, PM Macey, MA Woo… - Journal of …, 2005 - journals.physiology.org
Congenital central hypoventilation syndrome (CCHS) patients show impaired ventilatory
responses and loss of breathlessness to hypercapnia, yet arouse from sleep to high CO2 …

Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndrome

PM Macey, MA Woo, KE Macey… - Journal of Applied …, 2005 - journals.physiology.org
Congenital central hypoventilation syndrome (CCHS) patients show deficient respiratory
and cardiac responses to hypoxia and hypercapnia, despite apparently intact arousal …

[HTML][HTML] FMRI responses to hyperoxia in congenital central hypoventilation syndrome

MA Woo, PM Macey, KE Macey, TG Keens… - Pediatric …, 2005 - nature.com
Abstract Congenital Central Hypoventilation Syndrome (CCHS) patients show partial
retention of peripheral chemoreception despite impaired ventilatory responses to CO 2 and …

[HTML][HTML] Aberrant neural responses to cold pressor challenges in congenital central hypoventilation syndrome

PM Macey, KE Macey, MA Woo, TG Keens… - Pediatric …, 2005 - nature.com
Patients with congenital central hypoventilation syndrome (CCHS), a condition
characterized by impaired ventilatory responses to chemoreceptor stimulation, do not show …

fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome

KE Macey, PM Macey, MA Woo… - Journal of applied …, 2004 - journals.physiology.org
Congenital central hypoventilation syndrome (CCHS) patients show impaired ventilatory
responses to CO2 and hypoxia and reduced drive to breathe during sleep but retain …

Neuroanatomic deficits in congenital central hypoventilation syndrome

R Kumar, PM Macey, MA Woo, JR Alger… - Journal of …, 2005 - Wiley Online Library
Abstract Congenital Central Hypoventilation Syndrome (CCHS) patients exhibit
compromised autonomic regulation, reduced breathing drive during sleep, diminished …

Central autonomic regulation in congenital central hypoventilation syndrome

JA Ogren, PM Macey, R Kumar, MA Woo, RM Harper - Neuroscience, 2010 - Elsevier
Congenital central hypoventilation syndrome (CCHS) patients show significant autonomic
dysfunction in addition to the well-described loss of breathing drive during sleep. Some …

Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome

PM Macey, JR Alger, R Kumar, KE Macey… - Respiratory physiology …, 2003 - Elsevier
We evaluated global blood oxygen level dependent (BOLD) signal changes in gray and
white matter in 14 congenital central hypoventilation syndrome (CCHS) and 14 control …

[HTML][HTML] Temporal trends of cardiac and respiratory responses to ventilatory challenges in congenital central hypoventilation syndrome

PM Macey, C Valderama, AH Kim, MA Woo… - Pediatric …, 2004 - nature.com
Congenital central hypoventilation syndrome (CCHS) patients exhibit respiratory deficits to
ventilatory challenges, diminished breathing drive during sleep, and reduction of respiratory …

Peripheral chemoreceptors in congenital central hypoventilation syndrome

IA Perez, TG Keens - Respiratory physiology & neurobiology, 2013 - Elsevier
Congenital central hypoventilation syndrome is a rare disorder caused by a mutation in the
PHOX2B gene resulting in hypoventilation that is worse during sleep. Human physiologic …