Objective: Duloxetine doses of 80 and 120 mg/day were assessed for efficacy and safety in
the treatment of major depressive disorder (MDD). Methods: In this randomized, double …

Objective Return of functional ability is a central goal in the treatment of major depressive
disorder. We conducted two trials with the same protocol that was designed to assess …

Objective: To evaluate duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine,
on improvement of emotional and painful physical symptoms. Design: Randomized, double …

Background: This study was designed to assess clinical and functional outcomes associated
with switching to duloxetine treatment in patients with major depressive disorder (MDD) …

Painful physical symptoms (PPS) are common in patients with depression. Our objective
was to evaluate the presence of PPS in a sample of SSRI non-or partial-responders with …

Background: Depression is underdiagnosed in the primary care setting. Physical symptoms
such as aches, pains, and gastrointestinal disturbance are frequently associated with major …

Background. This study compares the efficacy and tolerability of 12 weeks of open-label
duloxetine in adult outpatients with anxious versus non-anxious depression. Methods …

Background: Uncontrolled antidepressant trials suggest that anxious patients with major
depressive disorder (MDD) are less responsive to antidepressant treatment than less …

The objective of this paper is to better understand the relationship of pain and mood in
patients with fibromyalgia and comorbid major depressive disorder (MDD). Pooled data from …

To examine the long‐term safety, tolerability, and effectiveness of duloxetine in the treatment
of major depressive disorder in a naturalistic study design meant to mimic clinical practice …