BACKGROUND: Major depressive disorders (MDD) present a significant public health
problem, in terms of burden for individual sufferers, their families and society as a whole …

Objective: A number of studies have suggested potential gender differences in the efficacy of
antidepressant medications. Pooled data from double-blind, placebo-controlled studies …

The aim of the present paper was to compare the efficacy and safety of duloxetine with
paroxetine in the acute treatment of major depressive disorder (MDD). In a randomized …

We evaluated individual patient data from phase II to IV clinical trials of duloxetine in major
depressive disorder (MDD)(34 studies, 13,887 patients). Our goal was to identify clusters of …

The aim of the study was to determine whether baseline pain was associated with
discernible clinical features and treatment outcomes for patients with major depressive …

Background Concomitant painful physical symptoms in depressive patients frequently impair
functioning and failure to treat these symptoms may adversely impact treatment outcomes of …

Background Approximately two-thirds of patients with depression experience physical pain
symptoms. Coexisting pain complicates the treatment of depression and is associated with …

Objective Pain commonly coexists with depression, but its impact on treatment outcomes
has not been well studied. Therefore, we prospectively evaluated the impact of comorbid …

Background: Although major depression and chronic headache are strongly associated,
there is insufficient evidence for the use of antidepressants for this specific comorbidity. This …

Background: Depression is a chronic recurring disorder and guidelines recommend long-
term therapy. This clinical trial evaluated the long-term (1 year) safety and efficacy of …