This work discusses a stochastic approach for the calculation of robust anti-solvent addition
policies for controlling the mean crystal size (MCS) and prediction of the crystal size …

This article presents a model‐based control approach for optimal operation of a seeded fed‐
batch evaporative crystallizer. Various direct optimization strategies, namely, single …

Crystallization is a complex process of heat and mass transfer, its product quality is affected
by many factors, thus it is a challenge to control this process. Modelling and optimization of …

This academic publication provides an overview of constant crystallization of solutions in the
pharmaceutical industry. The comparison of continuous versus batch crystallizers, their …

The paper presents an experimental validation of a novel methodology for the systematic
design of the set point operating curves for supersaturation-controlled, seeded crystallization …

The purpose of this study was to develop an integrated control strategy for multiscale
crystallization processes. An image analysis method using a deep learning neural network …

In this article, a new approach to the control of batch cooling crystallizers is presented. In
batch cooling crystallization, the crucial control problem is to design a temperature trajectory …

In pharmaceuticals manufacturing, the conversion of conventional batch crystallisations to
continuous mode has the potential for intensified, compact operation and more consistent …

Crystallization is the most important unit operation for the separation and purification of
chemicals in the pharmaceutical and fine chemical industries. Crystallization processes in …

The uncertainty in crystallization kinetics is of major concern in manufacturing processes,
which can result in deterioration of most model‐based control strategies. In this study …