The 5-HT1A receptor has been extensively studied over the last two decades. There is a
plethora of information describing its anatomical, physiological and biochemical roles in the …

Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …

The complexities of the involvement of the serotonin transmitter system in numerous
biological processes and psychiatric disorders is, to a substantial degree, attributable to the …

Despite the better understanding of the mechanisms underlying Alzheimer's Disease (AD)
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …

Among an impressive variety of identified serotonin receptors, 5-HT 1A attracts particular
attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the …

Recent evidence suggests that 5-hydroxytryptamine (5-HT) 4 receptor activity enhances
cognition and provides neuroprotection. Here we report the effects of VRX-03011, a novel …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Abstract Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is
associated with a high degree of morbidity and mortality. This debilitating disorder is …

The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of
emotional processes and a target of medications used in the treatment of psychiatric …

A comprehensive, state-of-the-art review of our current understanding of the molecular and
structural biology of 5-HT receptors and their potential use for drug discovery. The authors …