Unmet need: what justifies the search for a new antidepressant?
JF Greden - Journal of Clinical Psychiatry, 2002 - psychiatrist.com
The burden of major depressive disorder is huge, as is clearly documented by World Health
Organization data. A major component of this burden is the episodic nature of depression …
Organization data. A major component of this burden is the episodic nature of depression …
{Clinical Issues in Long-Term Treatment With Antidepressants
JM Zajecka - Journal of Clinical Psychiatry, 2000 - psychiatrist.com
Historically, the emphasis in treating depression has been focused on the acute phase of
treatment, with few published data on the continuation and maintenance phases of …
treatment, with few published data on the continuation and maintenance phases of …
Are antidepressants as effective as claimed? Yes, but…
L Ravindran, SH Kennedy - The Canadian Journal of …, 2007 - journals.sagepub.com
Canada and a lifetime prevalence of 8%. 1 The human cost of the illness in terms of
impaired social and emotional functioning cannot be emphasized enough, and the societal …
impaired social and emotional functioning cannot be emphasized enough, and the societal …
Problems with currently available antidepressants
JF Gumnick, CB Nemeroff - Journal of Clinical Psychiatry, 2000 - psychiatrist.com
Although options for pharmacologic treatment for depression have grown seemingly
exponentially over the past several decades, the current armamentarium of antidepressants …
exponentially over the past several decades, the current armamentarium of antidepressants …
Why settle for silver, when you can go for gold? Response vs. recovery as the goal of antidepressant therapy
SM Stahl - Journal of Clinical Psychiatry, 1999 - psychiatrist.com
The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …
to better recognition of those with depression, and also to a reduction in the number of …
Targeting treatment-resistant depression
M Mathys, BG Mitchell - Journal of Pharmacy Practice, 2011 - journals.sagepub.com
Only 50% of depressed patients achieve remission of symptoms after 2 trials of
antidepressants. Therefore one half of patients are considered treatment resistant. Studies …
antidepressants. Therefore one half of patients are considered treatment resistant. Studies …
Which depressed patients should receive antidepressants?
WA Brown, A Khan - CNS Drugs, 1994 - Springer
Antidepressants lead to improvement in about 70% of unselected patients with a depressive
syndrome. However, many of these patients would also improve with the passage of time …
syndrome. However, many of these patients would also improve with the passage of time …
Are all antidepressants the same?
HJ Moller - Journal of Clinical Psychiatry, 2000 - psychiatrist.com
Historically, the clinician's choice of antidepressant agent has been determined largely by
consideration of tolerability, given the perception that the therapeutic efficacy of the various …
consideration of tolerability, given the perception that the therapeutic efficacy of the various …
Pharmacotherapy for treatment-resistant depression: antidepressants and atypical antipsychotics
C Vas, A Jain, M Trivedi, MK Jha… - Psychiatric …, 2023 - psych.theclinics.com
Major depressive disorder (MDD) is an often chronic and/or recurrent disorder that is
associated with dysfunctions in multiple aspects of life including work and non-workrelated …
associated with dysfunctions in multiple aspects of life including work and non-workrelated …
Current antidepressant drugs: their clinical use
LE Hollister - Drugs, 1981 - Springer
Depression is not only a common disorder, but also one that is readily treatable.
Antidepressant drugs play a major role in treatment, although concurrent use of …
Antidepressant drugs play a major role in treatment, although concurrent use of …