Major depressive disorder (MDD) is a severe and chronic psychiatric disorder with a high
prevalence in the population. Although our understanding of its pathophysiological …

Depression is a debilitating psychiatric disorder with a high rate of relapse and a low rate of
response to antidepressant treatment. There is a dearth of new antidepressants due to an …

There is compelling evidence that epigenetic factors contribute to the manifestation of
depression, in which microRNA132 (miR-132) is suggested to play a pivotal role in the …

Background: Depression is a common medical condition with a high prevalence leading to
emotional abnormality. Despite some drawbacks, depression currently diagnosed using a …

Depression is a potentially life-threatening mental disorder with unknown etiology. Several
microRNAs (miRNAs) have been shown to play critical roles in the etiology of depression …

Major Depressive Disorder (MDD) represents a major global health concern, a body-mind
malady of rising prevalence worldwide nowadays. The complex network of mechanisms …

Depressive disorders have complex and multi-faceted underlying mechanisms, rendering
these disorders difficult to treat consistently and effectively. One under-explored therapeutic …

MicroRNAs (miRNA) are a class of small non-coding RNAs that have recently emerged as
epigenetic modulators of gene expression in psychiatric diseases like schizophrenia and …

There is a growing emphasis in the field of psychiatry on the need to identify candidate
biomarkers to aid in diagnosis and clinical management of depression, particularly with …

Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of
depression. Here we assessed whether miR-218 in the mPFC confers resilience or …