Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases,
respectively) are post-translational modifications that play key roles in many eukaryotic …

DNA topoisomerase (topo) IIα, an essential enzyme for cell proliferation, is targeted to a
proteasome-dependent degradation pathway when human tumor cells are glucose-starved …

Exogenously and endogenously originated signals are propagated within the cell by
functional and physical networks of proteins, leading to numerous biological outcomes …

Oct4 is essential to maintain pluripotency and has a pivotal role in establishing the germline.
Its DNA-binding POU domain was recently found to bind motifs with methylated CpG …

The O-GlcNAc transferase (OGT) modifies nuclear and cytoplasmic proteins with β-N-acetyl-
glucosamine (O-GlcNAc). With thousands of O-GlcNAc-modified proteins but only one OGT …

RNA‐binding proteins (RBPs) are essential players in RNA metabolism including key
cellular processes from pre‐mRNA splicing to mRNA translation. The K homology‐type …

Keap1 is a BTB-Kelch-type substrate adaptor protein of the Cul3-dependent ubiquitin ligase
complex. Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the …

Symplekin (Pta1 in yeast) is a scaffold in the large protein complex that is required for 3′-
end cleavage and polyadenylation of eukaryotic messenger RNA precursors (pre …

Summary Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively
COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis …

Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-
strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of …