Cell type-specific transcriptional differences between brain tissues from donors with
Alzheimer's disease (AD) and unaffected controls have been well documented, but few …

Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …

Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Abstract Knowledge about the molecular mechanisms driving Alzheimer's disease (AD) is
still limited. To learn more about AD biology, we performed whole transcriptome sequencing …

Alzheimer's disease (AD) is a complex multifactorial disorder with poorly characterized
pathogenesis. Our understanding of this disease would thus benefit from an approach that …

Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …

Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …