Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

New designed EGFR inhibitors (7-11) were prepared from the pyrazolo [3, 4-d] pyrimidine
intermediates 4a-d including different moieties. All newly synthesized compounds were …

This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

In the present investigation, we employed pyrrolo [2, 3-d] pyrimidine, potassium amide, and
liquid ammonia to synthesize pyrrolo [2, 3-d] pyrimidin-2-amine derivatives (4a-n) …

Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …

Abstract The pyrazolo [1, 5-a] pyrimidine core framework is a good starting point for the
synthesis of drug-like molecules since the biological activity is determined by the kind and …

The synthesis of some new quinoline‐thiazolidine‐2, 4‐dione coupled pyrazoles (7 a–7 n)
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …

Background: The Epidermal Growth Factor Receptor (known as EGFR) induces cell
differentiation and proliferation upon activation through the binding of its ligands. Since …

Background: The indole backbone is encountered in a class of N-heterocyclic compounds
with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti …