Myeloperoxidase–A bridge linking inflammation and oxidative stress with cardiovascular disease

G Ndrepepa - Clinica chimica acta, 2019 - Elsevier
Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease

N Anatoliotakis, S Deftereos, G Bouras… - Current topics in …, 2013 - ingentaconnect.com
Myeloperoxidase (MPO), a heme protein released by leukocytes, is one of the most widely
studied during the last decades molecule that plays a crucial role in inflammation and …

Myeloperoxidase as a multifaceted target for cardiovascular protection

CJA Ramachandra, KPMM Ja, J Chua… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Myeloperoxidase (MPO) is a heme peroxidase that is primarily expressed by
neutrophils. It has the capacity to generate several reactive species, essential for its inherent …

Myeloperoxidase and cardiovascular disease

SJ Nicholls, SL Hazen - Arteriosclerosis, thrombosis, and vascular …, 2005 - Am Heart Assoc
Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a
number of reactive oxidant species. In addition to being an integral component of the innate …

Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease

C Nussbaum, A Klinke, M Adam, S Baldus… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil
bactericidal proteins and is stored in large amounts inside azurophilic granules of …

Role of myeloperoxidase in inflammation and atherosclerosis

C Frangie, J Daher - Biomedical reports, 2022 - spandidos-publications.com
Myeloperoxidase (MPO) belongs to the heme peroxidase family, which includes a set of
enzymes with potent oxidoreductase activity. MPO is considered an important part of the …

Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease

SL Maiocchi, J Ku, T Thai, E Chan, MD Rees… - Pharmacology & …, 2021 - Elsevier
Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental
component of the innate immune response against microbial pathogens. In recent times …

Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification?

RK Schindhelm, LP van der Zwan, T Teerlink… - Clinical …, 2009 - academic.oup.com
Background: Inflammation and oxidative stress are associated with atherosclerosis.
Myeloperoxidase (MPO) is linked to both inflammation and oxidative stress by its location in …

Myeloperoxidase as an active disease biomarker: recent biochemical and pathological perspectives

AA Khan, MA Alsahli, AH Rahmani - Medical sciences, 2018 - mdpi.com
Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced
mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of …

Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease

BS Van der Veen, MPJ de Winther… - Antioxidants & redox …, 2009 - liebertpub.com
Abstract 2900 Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly
expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO …