IL-1α serves as a pro-inflammatory cytokine. Although pro-IL-1α has cytokine activity,
proteolytic maturation increases its potency and release from cells. IL-1α maturation occurs …

Pyroptosis is a type of regulated cell death executed by gasdermin family members.
However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear …

The gasdermin family is a newly identified class of pore-forming proteins that play as the
executioners of pyroptosis, a lytic pro-inflammatory type of cell death triggered by sensing …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

The death of a cell is an inevitable part of its biology. During homeostasis, most cells die
through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell
death associated with pathogen invasion and inflammation. After proteolytic cleavage by …

Since their discovery, members of the gasdermin (GSDM) family of proteins have been firmly
established as executors of pyroptosis, with the N-terminal fragment of most GSDMs capable …

Abstract Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N
domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we …

The pro‐inflammatory cytokine IL‐1β is well known for its role in host defense and the
initiation of potent inflammatory responses. It is processed from its inactive pro‐form by the …