Correction of vitamin D deficiency in critically ill patients-VITdAL@ ICU study protocol of a double-blind, placebo-controlled randomized clinical trial

K Amrein, C Schnedl, A Berghold, TR Pieber… - BMC endocrine …, 2012 - Springer
Background Vitamin D deficiency is associated with multiple adverse health outcomes
including increased morbidity and mortality in the general population and in critically ill …

Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled …

K Amrein, D Parekh, S Westphal, JC Preiser… - BMJ open, 2019 - bmjopen.bmj.com
Introduction Observational studies have demonstrated an association between vitamin D
deficiency and increased risk of morbidity and mortality in critically ill patients. Cohort studies …

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial

K Amrein, C Schnedl, A Holl, R Riedl, KB Christopher… - Jama, 2014 - jamanetwork.com
Importance Low vitamin D status is linked to increased mortality and morbidity in patients
who are critically ill. It is unknown if this association is causal. Objective To investigate …

Vitamin D deficiency in the ICU: a systematic review.

P Zajic, K Amrein - Minerva Endocrinologica, 2014 - europepmc.org
In the last decade, few substances have been discussed as controversially as vitamin D. In
the last few years, vitamin D research has now also found its way into the intensive care unit …

Efficacy of high-dose vitamin D supplementation in the critically ill patients

RM Perron, P Lee - … & Allergy-Drug Targets (Formerly Current …, 2013 - ingentaconnect.com
Vitamin D deficiency and its adverse skeletal sequelae are well recognized in the general
population. Recent observation of high prevalence of low vitamin D states and their …

Vitamin D supplementation in the ICU patient

KB Christopher - Current Opinion in Clinical Nutrition & Metabolic …, 2015 - journals.lww.com
Vitamin D deficiency is a potentially modifiable marker for adverse outcomes in critical
illness and critical illness survivors. Vitamin D supplementation is inexpensive and appears …

Vitamin D and critical illness: what endocrinology can learn from intensive care and vice versa

K Amrein, A Papinutti, E Mathew, G Vila… - Endocrine …, 2018 - ec.bioscientifica.com
The prevalence of vitamin D deficiency in intensive care units ranges typically between 40
and 70%. There are many reasons for being or becoming deficient in the ICU. Hepatic …

Vitamin D in the ICU: more sun for critically ill adult patients?

PL Langlois, F D'Aragon, W Manzanares - Nutrition, 2019 - Elsevier
Critical illness in patients is characterized by systemic inflammation and oxidative stress.
Vitamin D has a myriad of biological functions relevant to this population, including …

[HTML][HTML] Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients

National Heart, Lung, and Blood Institute … - … England Journal of …, 2019 - Mass Medical Soc
Background Vitamin D deficiency is a common, potentially reversible contributor to morbidity
and mortality among critically ill patients. The potential benefits of vitamin D supplementation …

How deficient are vitamin D deficient critically ill patients?

P Lee - Critical Care, 2011 - Springer
Vitamin D deficiency is highly prevalent among critically ill patients and may be associated
with adverse outcomes. Failure of conventional vitamin D supplementation in correcting …