Clinical studies demonstrate that estrogen replacement therapy in postmenopausal women
may enhance cognitive function and reduce neurodegeneration associated with Alzheimer's …

Estrogen replacement therapy in postmenopausal women ameliorates cognitive dysfunction
and decreases the risk and/or severity of neurodegenerative conditions such as Alzheimer's …

Background and Purpose—The importance of postmenopausal estrogen replacement
therapy for stroke in females remains controversial. We previously showed that female rats …

While human observational studies and animal studies report a neuroprotective role for
estrogen therapy in stroke, the multicenter placebo-controlled Women's Health Initiative …

Background and Purpose—Estrogen-related neuroprotection in association with animal
models of transient forebrain and focal ischemia has been documented in several recent …

Recent data from the Women's Health Initiative have highlighted many fundamental issues
about the utility and safety of long-term estrogen use in women. Current hormone …

Estrogen has demonstrated great potential as a therapeutic agent in focal ischemic brain
injury, as exogenous β-estradiol has proven beneficial in a variety of focal stroke models. In …

Estrogen can ameliorate brain damage in experimental models of focal cerebral ischemia. In
vitro, estrogen increases levels of apolipoprotein E (apoE), which also has neuroprotective …

Recent evidence suggests that reproductive steroids are important players in shaping stroke
outcome and cerebrovascular pathophysiologic features. Although women are at lower risk …

Recent studies describing the seemingly contradictory actions of estrogens in ischemic
stroke injury have led us to reevaluate the circumstances under which estrogen therapy (ET) …