Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents
SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
Design, synthesis, and antitumor activity of erlotinib derivatives
L Mao, ZZ Wang, Q Wu, X Chen, JX Yang… - Frontiers in …, 2022 - frontiersin.org
Nineteen erlotinib derivatives bearing different 1, 2, 3-triazole moieties were designed,
synthesized, and evaluated for their potential against different cancer cell lines. The …
synthesized, and evaluated for their potential against different cancer cell lines. The …
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
PC Lv, HQ Li, J Sun, Y Zhou, HL Zhu - Bioorganic & medicinal chemistry, 2010 - Elsevier
Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …
Novel 1, 3, 5-triazine-based pyrazole derivatives as potential antitumor agents and EFGR kinase inhibitors: Synthesis, cytotoxicity, DNA binding, molecular docking …
We herein report the design and synthesis of new 1, 3, 5-triazine-based pyrazole derivatives
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
Synthesis of Quinoline‐Thiazolidine‐2, 4‐dione Coupled Pyrazoles as in vitro EGFR Targeting Anti‐Breast Cancer Agents and Their in silico Studies
M Bangaru, S Kumar Nukala, PK Kannekanti… - …, 2023 - Wiley Online Library
The synthesis of some new quinoline‐thiazolidine‐2, 4‐dione coupled pyrazoles (7 a–7 n)
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …
Design, synthesis and biological evaluation of pyrazolyl-nitroimidazole derivatives as potential EGFR/HER-2 kinase inhibitors
XX Tao, YT Duan, LW Chen, DJ Tang, MR Yang… - Bioorganic & Medicinal …, 2016 - Elsevier
A series of novel pyrazole-nitroimidazole derivatives had been arranged and evaluated for
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …
Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors
PC Lv, CF Zhou, J Chen, PG Liu, KR Wang… - Bioorganic & medicinal …, 2010 - Elsevier
Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …
Synthesis and in vitro anticancer activity of 4H-pyrano [2, 3-d] pyrimidine− 1H-1, 2, 3-triazole hybrid compounds bearing D-glucose moiety with dual EGFR/HER2 …
Abstracts The polysubstituted 4H-pyrano [2, 3-d] pyrimidines 6a-zj containing propargyl
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …