In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

Nineteen erlotinib derivatives bearing different 1, 2, 3-triazole moieties were designed,
synthesized, and evaluated for their potential against different cancer cell lines. The …

Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …

We herein report the design and synthesis of new 1, 3, 5-triazine-based pyrazole derivatives
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …

The synthesis of some new quinoline‐thiazolidine‐2, 4‐dione coupled pyrazoles (7 a–7 n)
via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling …

A series of novel pyrazole-nitroimidazole derivatives had been arranged and evaluated for
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …

Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …

Abstracts The polysubstituted 4H-pyrano [2, 3-d] pyrimidines 6a-zj containing propargyl
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …