Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
G Yu, A Tzouvelekis, R Wang, JD Herazo-Maya… - Nature medicine, 2018 - nature.com
Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …
Single-cell RNA sequencing provides new insights into therapeutic roles of thyroid hormone in idiopathic pulmonary fibrosis
L Wang, Z Li, R Wan, X Pan, B Li, H Zhao… - American journal of …, 2023 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an
effective cure. Herein, we explore the role of 3, 5, 3′-triiodothyronine (T3) administration on …
effective cure. Herein, we explore the role of 3, 5, 3′-triiodothyronine (T3) administration on …
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
SM Cloonan, K Glass, ME Laucho-Contreras… - Nature medicine, 2016 - nature.com
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …
genetic determinants. We have previously identified iron-responsive element–binding …
Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation
Osteoclasts are acid-secreting polykaryons that have high energy demands and contain
abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast …
abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast …
Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice
Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems,
including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung …
including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung …
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type
2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis …
2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis …
Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β–mediated collagen production in a murine asthma model
OA Jaffer, AB Carter, PN Sanders… - American journal of …, 2015 - atsjournals.org
Asthma is a disease of acute and chronic inflammation in which cytokines play a critical role
in orchestrating the allergic inflammatory response. IL-13 and transforming growth factor …
in orchestrating the allergic inflammatory response. IL-13 and transforming growth factor …
Regulation of mitochondrial morphology and function by stearoylation of TFR1
D Senyilmaz, S Virtue, X Xu, CY Tan, JL Griffin… - Nature, 2015 - nature.com
Mitochondria are involved in a variety of cellular functions, including ATP production, amino
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …
Reducing protein oxidation reverses lung fibrosis
Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the
lung, leading to chronically impaired gas exchange and death,–. Oxidative stress is believed …
lung, leading to chronically impaired gas exchange and death,–. Oxidative stress is believed …
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats
GDC Massaro, D Massaro - Nature medicine, 1997 - nature.com
Pulmonary emphysema is a common disease1 in which destruction of the lung's gas-
exchange structures (alveoli) 2 leads to inadequate oxygenation3, disability4 and frequently …
exchange structures (alveoli) 2 leads to inadequate oxygenation3, disability4 and frequently …