[HTML][HTML] Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
D Lissa, N Takahashi, P Desai, I Manukyan… - Nature …, 2022 - nature.com
Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …
transcription regulators have recently been proposed in cell lines and limited number of …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study
Z Megyesfalvi, N Barany, A Lantos… - The Journal of …, 2022 - Wiley Online Library
The tissue distribution and prognostic relevance of subtype‐specific proteins (ASCL1,
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
A biobank of small cell lung cancer CDX models elucidates inter-and intratumoral phenotypic heterogeneity
KL Simpson, R Stoney, KK Frese, N Simms, W Rowe… - Nature Cancer, 2020 - nature.com
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …
[HTML][HTML] Prognostic implications of molecular subtypes in primary small cell lung cancer and their correlation with cancer immunity
J Qi, J Zhang, N Liu, L Zhao, B Xu - Frontiers in Oncology, 2022 - frontiersin.org
Introduction Small cell lung cancer (SCLC) has recently been characterized as
heterogeneous tumors due to consensus nomenclature for distinct molecular subtypes on …
heterogeneous tumors due to consensus nomenclature for distinct molecular subtypes on …
Small cell lung cancer: Subtypes and therapeutic implications
WZ Wang, A Shulman, JM Amann, DP Carbone… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
[HTML][HTML] New molecular classification of large cell neuroendocrine carcinoma and small cell lung carcinoma with potential therapeutic impacts
S Lantuejoul, L Fernandez-Cuesta… - … lung cancer research, 2020 - ncbi.nlm.nih.gov
Large cell neuroendocrine carcinoma (LCNECs) and small cell lung carcinomas (SCLCs)
are high-grade neuroendocrine carcinomas of the lung with very aggressive behavior and …
are high-grade neuroendocrine carcinomas of the lung with very aggressive behavior and …
[HTML][HTML] Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes
W Zhang, L Girard, YA Zhang, T Haruki… - … lung cancer research, 2018 - ncbi.nlm.nih.gov
Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution
Small cell lung cancer (SCLC) has recently been subcategorized into neuroendocrine (NE)‐
high and NE‐low subtypes showing 'immune desert'and 'immune oasis' phenotypes …
high and NE‐low subtypes showing 'immune desert'and 'immune oasis' phenotypes …
Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histologic transformation
Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …