[HTML][HTML] Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in …

DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

DA Gordon, H Jamil - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The microsomal triglyceride transfer protein (MTP) is necessary for the proper assembly of
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …

[HTML][HTML] The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational …

S Wang, RS McLeod, DA Gordon, Z Yao - Journal of Biological Chemistry, 1996 - ASBMB
We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis,
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by …

DA Gordon, H Jamil, D Sharp… - Proceedings of the …, 1994 - National Acad Sciences
To elucidate the role of the microsomal triglyceride transfer protein (MTP) in lipoprotein
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …

[HTML][HTML] The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 …

S Rustaeus, P Stillemark, K Lindberg, D Gordon… - Journal of Biological …, 1998 - ASBMB
In cells in which the lipoprotein assembly process had been inactivated by brefeldin A (BFA),
membrane-associated apoB-100 disappeared without forming lipoproteins or being …

[HTML][HTML] Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein

E Nicodeme, F Benoist, R McLeod, Z Yao… - Journal of Biological …, 1999 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for the assembly and
secretion of apoB-containing lipoproteins. To investigate the role of MTP in lipoprotein …

[HTML][HTML] Folding of the amino-terminal domain of apolipoprotein B initiates microsomal triglyceride transfer protein-dependent lipid transfer to nascent very low density …

MF Ingram, GS Shelness - Journal of Biological Chemistry, 1997 - ASBMB
The initial assembly of apolipoprotein B100 (apoB) into lipoprotein particles occurs
cotranslationally. To examine steps required to initiate this process, the intracellular folding …

The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein …

N Dashti, M Gandhi, X Liu, X Lin, JP Segrest - Biochemistry, 2002 - ACS Publications
Apolipoprotein (apo) B, the major protein component of the atherogenic low-density
lipoprotein (LDL), has a pentapartite structure, NH2-βα1-β1-α2-β2-α3-COOH, the β domains …

Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly

DA Gordon - Current opinion in lipidology, 1997 - journals.lww.com
The microsomal triglyceride transfer protein is necessary for the assembly and secretion of
lipoproteins containing apolipoprotein B. During the past year, significant progress has been …

[HTML][HTML] Demonstration of a Physical Interaction between Microsomal Triglyceride Transfer Protein and Apolipoprotein B during the Assembly of ApoB-containing …

X Wu, M Zhou, LS Huang, J Wetterau… - Journal of Biological …, 1996 - ASBMB
Microsomal triglyceride (TG) transfer protein (MTP) is an endoplasmic reticulum lumenal
protein consisting of a 97-kDa subunit and protein disulfide isomerase. It is believed that …