Certain vertebrate immune cells have evolved receptors that detect the presence of
pathogen DNA based on its content of unmethylated CpG dinucleotides in particular base …

Oligodeoxynucleotides containing CpG dinucleotides in specific sequence contexts activate
the vertebrate immune system. Our previous studies showed that the 5′-end of a CpG …

Bacterial DNA and synthetic oligonucleotides (ODN) containing unmethylated cytidine-
phosphate guanosine dinucleotide (CpG) motifs (CpG-ODN) stimulate a rapid innate …

Bacterial DNA with CpG motifs can efficiently stimulate the vertebrate immune system. Thus,
synthetic oligodeoxynucleotides that contain such CpG motifs (CpG-ODN) are currently used …

Oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within specific
sequence contexts (CpG motifs) are detected, like bacterial or viral DNA, as a danger signal …

Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …

A specific set of immune functions is switched on in response to DNA containing
unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Plasmids, viral …

Oligodinucleotides containing CpG motifs stimulate vertebrate immune cells in vitro, have
proven efficacy in murine disease models and are currently being tested in human clinical …

Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …

Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to
activate the innate immune system. The resultant response limits the early spread of …