Synthetic oligodeoxynucleotides (ODNs) bearing CpG dinucleotides can mimic the
immunostimulatory effects of bacterial DNA in vertebrates. Besides the known CpG motifs …

The immune system appears to have evolved a mechanism to detect prokaryotic nucleic
acids based on their content of unmethylated CpG dinucleotides in particular base contexts …

Bacterial and synthetic DNAs, containing CpG dinucleotides in specific sequence contexts,
activate the vertebrate immune system. Unlike phosphorothioate (PS) CpG DNAs …

Synthetic oligodeoxyribonucleotides containing CpG dinucleotides exhibit potent
immunostimulatory activity in vertebrates. Although the molecular mechanisms of …

Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG
motifs stimulate a strong innate immune response. This stimulation can be abrogated by …

Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated “CpG
motifs” stimulate an innate immune response characterized by the production of cytokines …

Aside from its function as the “blueprint of life” that encodes genetic information, DNA can
have direct immune activities. The immune system has evolved a defense mechanism that is …

The vertebrate immune system recognizes bacterial DNA as foreign based on its content of
unmethylated CpG motifs. The detection of CpG motifs by the innate immune system induces …

The goal of using of oligodeoxyribonucleotides containing CpG dinucleotides (CpG DNA) as
immunomodulatory agents has been realized in recent years. Therapeutic applications of …

Oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within specific
sequence contexts (CpG motifs) are detected, like bacterial or viral DNA, as a danger signal …