Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences
D Yu, ER Kandimalla, Y Cong, J Tang… - Journal of medicinal …, 2002 - ACS Publications
Bacterial and synthetic DNA containing unmethylated CpG dinucleotides activate the innate
immune system and promote Th1-like immune responses. Recently, a receptor, TLR9, has …
immune system and promote Th1-like immune responses. Recently, a receptor, TLR9, has …
Conjugation of ligands at the 5 '-end of CpG DNA affects immunostimulatory activity
ER Kandimalla, L Bhagat, D Yu, Y Cong… - Bioconjugate …, 2002 - ACS Publications
Bacterial DNA and synthetic oligonucleotides containing unmethylated CpG dinucleotides
(CpG DNA) activate the vertebrate immune system and promote Th1-like immune …
(CpG DNA) activate the vertebrate immune system and promote Th1-like immune …
Use of CpG oligodeoxynucleotides as immunoprotective agents
DM Klinman - Expert opinion on biological therapy, 2004 - Taylor & Francis
Single-stranded oligodeoxynucleotides (ODNs) synthesised to express unmethylated 'CpG
motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs …
motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs …
[HTML][HTML] CpG DNA: recognition by and activation of monocytes
Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …
Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants
DM Klinman, S Klaschik, K Tomaru, H Shirota, D Tross… - Vaccine, 2010 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and …
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and …
Adjuvant activity of CpG oligodeoxynucleotides
DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
CpG oligodeoxynucleotides stimulate canine and feline immune cell proliferation
CM Wernette, BF Smith, ZL Barksdale, R Hecker… - Veterinary immunology …, 2002 - Elsevier
Oligodeoxynucleotides (ODNs) with unmethylated CpG dinucleotide motifs may be useful as
non-specific immune system stimulants and adjuvants for protein or nucleic acid vaccines in …
non-specific immune system stimulants and adjuvants for protein or nucleic acid vaccines in …
Medicinal chemistry and therapeutic potential of CpG DNA
S Agrawal, ER Kandimalla - Trends in molecular medicine, 2002 - cell.com
The observation that oligodeoxynucleotides containing CpG dinucleotides (CpG DNA)
exhibit several immunological effects has led to their use as therapeutic agents and …
exhibit several immunological effects has led to their use as therapeutic agents and …
The role of CpG dinucleotides in DNA vaccines
AM Krieg, AK Yi, J Schorr, HL Davis - Trends in microbiology, 1998 - cell.com
DNA vaccines can induce potent humoral and cellular immune responses without any
additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within …
additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within …
CpG motifs for optimization of DNA vaccines.
HL Davis - Developments in biologicals, 2000 - europepmc.org
The immunogenicity of DNA vaccines is due in part to the presence of stimulatory CpG
motifs, which may actually be essential to their function. CpG motifs are unmethylated …
motifs, which may actually be essential to their function. CpG motifs are unmethylated …