CpG oligodeoxynucleotides as vaccine adjuvants in primates
D Verthelyi, RT Kenney, RA Seder, AA Gam… - The journal of …, 2002 - journals.aai.org
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
[引用][C] An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
AM Krieg - Journal of Laboratory and Clinical Medicine, 1996 - Elsevier
B iologists have been so used to thinking of DNA as the blueprint of life that it may be difficult
to accept the notion that DNA may be used as a signaling molecule, too. Over the past …
to accept the notion that DNA may be used as a signaling molecule, too. Over the past …
'Immunomers'—novel 3′–3′‐linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents
D Yu, ER Kandimalla, L Bhagat, JY Tang… - Nucleic acids …, 2002 - academic.oup.com
Abstract Oligodeoxyribonucleotides containing CpG dinucleotides (CpG DNAs) are currently
being evaluated as novel immunomodulators in clinical trials. Recently, we showed that an …
being evaluated as novel immunomodulators in clinical trials. Recently, we showed that an …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Three CpG oligodeoxynucleotide classes differentially enhance antigen-specific humoral and cellular immune responses in mice
Y Liu, X Luo, C Yang, S Yu, H Xu - Vaccine, 2011 - Elsevier
Synthetic oligodeoxynucleotides containing unmethylated CpG-dinucleotides (CpG-ODNs)
are immunostimulatory in a broad spectrum of species. Extensive studies provide evidence …
are immunostimulatory in a broad spectrum of species. Extensive studies provide evidence …
The potential of CpG oligodeoxynucleotides as mucosal adjuvants.
MJ McCluskie, RD Weeratna, PJ Payette… - Critical reviews in …, 2001 - europepmc.org
The development of mucosal vaccines for humans has been hindered by the lack of safe yet
effective mucosal adjuvants. Bacterial toxins are commonly used as adjuvants in animal …
effective mucosal adjuvants. Bacterial toxins are commonly used as adjuvants in animal …
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides
Unmethylated CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides activate
immune cells that express Toll-like Receptor 9. Activation through this receptor triggers …
immune cells that express Toll-like Receptor 9. Activation through this receptor triggers …
CpG motifs as immune adjuvants
DM Klinman, KM Barnhart, J Conover - Vaccine, 1999 - Elsevier
Bacterial DNA contains immunostimulatory motifs that trigger an innate immune response
characterized by the production of predominantly Th1-type cytokines. These motifs consist of …
characterized by the production of predominantly Th1-type cytokines. These motifs consist of …
Immunostimulatory DNA as adjuvant: efficacy of phosphodiester CpG oligonucleotides is enhanced by 3′ sequence modifications
S Zimmermann, K Heeg, A Dalpke - Vaccine, 2003 - Elsevier
The immunostimulatory activity of oligonucleotides containing CpG motifs is well established
and represents the basis for an effective vaccine adjuvant. For use in vivo CpG ODN have to …
and represents the basis for an effective vaccine adjuvant. For use in vivo CpG ODN have to …