Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues
M Numazaki, T Tominaga, H Toyooka… - Journal of Biological …, 2002 - ASBMB
The capsaicin receptor, VR1, is a sensory neuron-specific ion channel that serves as a
polymodal detector of pain-producing chemical and physical stimuli. It has been reported …
polymodal detector of pain-producing chemical and physical stimuli. It has been reported …
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
G Bhave, W Zhu, H Wang, DJ Brasier, GS Oxford… - Neuron, 2002 - cell.com
The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel
expressed on nociceptive sensory neurons that responds to noxious thermal and chemical …
expressed on nociceptive sensory neurons that responds to noxious thermal and chemical …
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
M Tominaga, M Wada, M Masu - Proceedings of the …, 2001 - National Acad Sciences
The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. It has been …
as a polymodal detector of pain-producing chemical and physical stimuli. It has been …
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding
J Jung, JS Shin, SY Lee, SW Hwang, J Koo… - Journal of Biological …, 2004 - ASBMB
Vanilloid receptor 1 (VR1), a capsaicin receptor, is known to play a major role in mediating
inflammatory thermal nociception. Although the physiological role and biophysical …
inflammatory thermal nociception. Although the physiological role and biophysical …
Low pH potentiates both capsaicin binding and channel gating of VR1 receptors
S Ryu, B Liu, F Qin - The Journal of general physiology, 2003 - rupress.org
Capsaicin ion channels are highly expressed in peripheral nervous terminals and involved
in pain and thermal sensations. One characteristic of the cloned VR1 receptor is its …
in pain and thermal sensations. One characteristic of the cloned VR1 receptor is its …
The tissue distribution and functional characterization of human VR1
DN Cortright, M Crandall, JF Sanchez, T Zou… - Biochemical and …, 2001 - Elsevier
The irritant action of capsaicin is mediated by the vanilloid receptor, VR1, which is
expressed in sensory neurons termed nociceptors. Capsaicin also desensitizes nociceptors …
expressed in sensory neurons termed nociceptors. Capsaicin also desensitizes nociceptors …
Induction of vanilloid receptor channel activity by protein kinase C
LS Premkumar, GP Ahern - Nature, 2000 - nature.com
Capsaicin or vanilloid receptors (VRs) participate in the sensation of thermal and
inflammatory pain,,. The cloned (VR1) and native VRs are non-selective cation channels …
inflammatory pain,,. The cloned (VR1) and native VRs are non-selective cation channels …
Acid potentiation of the capsaicin receptor determined by a key extracellular site
SE Jordt, M Tominaga, D Julius - Proceedings of the …, 2000 - National Acad Sciences
The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
G Bhave, HJ Hu, KS Glauner, W Zhu… - Proceedings of the …, 2003 - National Acad Sciences
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
Molecular cloning of an N-terminal splice variant of the capsaicin receptor: loss of N-terminal domain suggests functional divergence among capsaicin receptor …
MA Schumacher, I Moff, SP Sudanagunta… - Journal of Biological …, 2000 - ASBMB
Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to
encode an ion channel that is activated by both capsaicin, the pain producing compound in …
encode an ion channel that is activated by both capsaicin, the pain producing compound in …