Ivabradine (Iva), a heart rate reducing agent that specifically inhibits the pacemaker I (f) ionic
current, has been demonstrated to be cardioprotective in many cardiovascular diseases …

Abstract Ischemia/reperfusion (I/R)-induced autophagy increases the severity of
cardiomyocyte injury. The aim of this study was to investigate the effects of berberine, a …

Background: Myocardial ischaemia/reperfusion (I/R) results in myocardial injury via
excessive autophagy. Huoxue Jiedu Formula (HJF) has been widely applied in China for the …

Trimetazidine (TMZ) has been demonstrated to have protective effects against myocardial
ischemia/reperfusion (MI/R) injury. In the present study, we investigated the effects and the …

The current study aimed to investigate the effects of tetramethylprazine (TMP) on myocardial
ischemia/reperfusion (MI/R) injury and its underlying mechanisms. MI/R rat model and …

The mechanisms underlying the myocardial protection of valsartan against
ischemia/reperfusion (I/R) injury are complicated and remain unclear. The aim of this study …

Metformin (Met) is a major widely used oral glucose lowering drug for the treatment of type 2
diabetes. It is reported that metformin could regulate autophagy in various diseases of …

Excessive autophagy induced by reperfusion is one of the causes of severe myocardial
injury. Tanshinone IIA (TSN) protects the myocardium against ischemia/reperfusion (I/R) …

Background The pathogenesis of myocardial ischemia/reperfusion is complex, involving
multiple regulatory genes and environmental factors, and requiring the simultaneous …

Objective: Apoptosis and autophagy are significant factors of sepsis induced myocardial
injury (SIMI). XBJ improves SIMI by PI3K/AKT/mTOR pathway. Present study is devised to …