lncRNA GAS5 suppresses rheumatoid arthritis by inhibiting miR-361-5p and increasing PDK4

W Zhang, B Li, N Xia, L Zhu, Z Zhang, Z Ren… - Biochemical and …, 2021 - Elsevier
Rheumatoid arthritis (RA) is an inflammatory disease that causes hyperplasia of synovial
tissue and cartilage destruction. This research was to investigate the effects of lncRNA …

Long non-coding RNA GAS5 suppresses rheumatoid arthritis progression via miR-128-3p/HDAC4 axis

T Peng, D Ji, Y Jiang - Molecular and Cellular Biochemistry, 2021 - Springer
Rheumatoid arthritis (RA) is a highly relevant public health problem. RA fibroblast-like
synoviocytes (RAFLSs) play an important role in RA progression. Long non-coding RNA …

[PDF][PDF] LncRNA GAS5 induces chondrocyte apoptosis by down-regulating miR-137.

ST Gao, YM Yu, LP Wan, ZM Liu… - European Review for …, 2020 - europeanreview.org
OBJECTIVE: Long non-coding RNA (lncRNA) participates in the pathogenesis of human
knee osteoarthritis (KOA). Growth arrest specificity 5 (GAS5) is a member lncRNA, but its …

LncRNA GAS5 upregulates Smad4 to suppress the apoptosis of chondrocytes induced by lipopolysaccharide

D Zhang, S Qiu - Archives of Gerontology and Geriatrics, 2021 - Elsevier
Background: Osteoarthritis (OA) is closely correlated with inflammation. It has been reported
that lncRNA GAS5 plays an important role in inflammation, indicating the potential …

LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis

Z Yang, SD Lin, F Zhan, Y Liu, YW Zhan - Autoimmunity, 2021 - Taylor & Francis
Introduction Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of
people. Fibroblast-like synoviocytes (FLSs) located in rheumatoid panni play a pivotal role in …

[HTML][HTML] Clinical significance and mechanism of LncRNA GAS-5 in osteoarthritis

H Zhang, Y Wu, W Li, H Chen - American Journal of Translational …, 2021 - ncbi.nlm.nih.gov
Objective: To investigate the clinical significance and mechanism of LncRNA GAS-5 in
osteoarthritis. Methods: 67 patients with knee osteoarthritis (the case group) and 60 patients …

LncRNA GAS5 activates the AMPK pathway in peripheral blood mononuclear cells derived from rheumatoid arthritis patients

J Cao, X Lv, Y Zhang, A Xu… - International journal of …, 2020 - Wiley Online Library
Background Rheumatoid arthritis (RA) is an inflammatory disease, which seriously affects
human joints. This study aimed to detect the changes in the expression of long non‐coding …

Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis

Q Ji, X Qiao, Y Liu, D Wang… - Molecular Medicine …, 2020 - spandidos-publications.com
The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA)
growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory …

Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes

Q Ji, X Qiao, Y Liu, D Wang - 2021 - digitum.um.es
Objective. To investigate the expression of long-chain noncoding RNA GAS5 in
osteoarthritis (OA) and the effect of silencing GAS5 on autophagy of osteoarthritis …

LncRNA GAS5 suppresses CD4+ T cell activation by upregulating E4BP4 via inhibiting miR-92a-3p in systemic lupus erythematosus

Q Liu, YA Deng, C Li, H Xie, Q Liu, S Ming, D Wu… - Immunology letters, 2020 - Elsevier
Increasing evidence reveals that long noncoding RNAs (lncRNAs) are associated with
autoimmune and inflammatory diseases, such as systemic lupus erythematosus (SLE). In …