The frequency of bcl-2 protein expression was evaluated using immunocytochemical
staining during the progression of human and rat prostate cancer from an androgen …

Normal (nonneoplastic) human prostatic secretory epithelial cells do not express the bcl-2
protein. However, a recent immunohistochemical survey of neoplastic human prostate …

The Bcl-2 protein prolongs cell survival by overriding apoptosis. To explore the role of Bcl-2
in prostate tumorigenesis, immunoreactivity for Bcl-2 was examined in untreated and …

Proteins encoded by bcl-2 family genes are important regulators of programmed cell death
and apoptosis. Alterations in the expression of these apoptosis-regulating genes can …

The significance of apoptosis in relation to the development and progression of prostate
cancer remains largely undefined, bcl-2 is an oncogene that functions by overriding …

The clinical course of prostate cancer is highly variable and cannot satisfactorily be
predicted by histological criteria alone. To study the prognostic significance of Bcl-2 and p53 …

Prostate cancer (PC) is an escalating health burden in the western world. A large number of
patients still present with extraprostatic (ie, T3/T4, N0, M0/M1 or any T category and M1 …

The oncoprotein encoded by bc1-2 is unique because of its intracellular location (a
mitochondrial membrane protein) and apparent mode of action (suppression of apoptosis) …

Prostatic adenocarcinoma has a divergent response to androgen ablation and a varied long-
term prognosis. BCL-2 is a proto-oncogene that prevents programmed cell death. Since …

Background: Cancer cells often develop mechanisms to resist apoptosis and the extent of
such anti‐apoptotic ability has been shown to parallel tumor progression in various …